Guy is her name, and she's a girl. She's just a very guyish girl whom is coincidentially named Guy. She's manlier than the Guy on the left. Makes you question whether he's really a guy, and whether Guy is really a girl, or if Guy is actually a Guy. Then there's Frank, we have no idea who he is, he's just Frank. Guy is a girl with two guys whom are both a very wimpy guy and a very strange guy whom is probably an alien.
In summary. Wayne Dies, Don't F!@# with Guy, and Frank is just Frank.